Multiple myeloma occurs when normal bone marrow cells become cancerous. Learn more about the symptoms and causes of multiple myeloma. Most people with multiple myeloma do not have clearly identifiable risk factors, but it may be more common in people who are exposed to certain chemicals. Myeloma bone disease is thought to result from overexpression of RANKL by bone marrow stroma. RANKL activates osteoclasts, which resorb bone. Bone breakdown. The causes of myeloma are unknown. Certain chemicals, high levels of radiation (such as from working in a nuclear power plant) and viruses (such as HIV) have. Penn Medicine specializes in multiple myeloma, a cancer that starts in bone marrow plasma cells. Learn the first signs and symptoms of multiple myeloma.

We don't know what causes most cases of multiple myeloma; most often, it develops in patients with no known risk factors. But risk factors that have been. The cause of multiple myeloma is unknown. Risk factors include obesity, radiation exposure, family history, age and certain chemicals. There is an increased. Risk Factors for Multiple Myeloma · Age · Sex · Race · Family history · Excess body weight · Having other plasma cell diseases. We do not fully understand the cause of myeloma. The changes in plasma cells are acquired, not inherited, but research shows a slight increase in the incidence. The cause of myeloma is not known. Some people who develop myeloma have been exposed to high doses of radiation. Others have had ongoing exposure to other. Multiple myeloma causes are largely unknown. Through extensive research, scientists have learned that this form of cancer develops when plasma cells in the. Myeloma, also called multiple myeloma, is a cancer of the plasma cells. Plasma cells are white blood cells that make antibodies that protect us from infection. Age. Most cases of multiple myeloma are diagnosed in people age 65 and older. Only 2% of cases happen in people under · Race. Black people are twice as. When these plasma cells start growing in an uncontrolled way in the bone marrow, it may lead to multiple myeloma, or myeloma, which is cancer of the plasma. Most of the problems it causes are because of a build up of abnormal plasma cells in the bone marrow and the paraprotein in the body. Myeloma affects areas. Multiple myeloma is cancer that starts in plasma cells in your bone marrow. · With multiple myeloma, tumors can form in the bones. · Some people have no symptoms.

Exposure to toxic chemicals, atomic radiation, anything that interferes with the immune system, or infection with cancer-causing viruses, may potentially be. Causes of multiple myeloma. It's not known exactly what causes multiple myeloma. However, there is a close link between multiple myeloma and a condition called. Because myeloma frequently occurs at many sites in the bone marrow, it is often referred to as multiple myeloma. Am I at Risk? Signs and symptoms of myeloma. Build up in the bone marrow · Produce proteins (monoclonal protein) that may damage the kidneys · Weaken the bone, leading to fractures · Cause tumors (abnormal. Multiple myeloma is a rare form of cancer characterized by excessive production (proliferation) and improper function of certain cells (plasma cells) found in. What Causes Myeloma? Myeloma develops when plasma cells — infection-fighting blood cells in the immune system — become abnormal and grow and divide. Causes. The cause of multiple myeloma is unknown. Past treatment with radiation therapy increases the risk for this type of cancer. Multiple myeloma mainly. (Myelomatosis; Plasma Cell Myeloma) Multiple myeloma is a cancer of plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and. Widespread growth of the malignant (cancerous) plasma cells in the bone marrow may leave little room for normal blood cells. This causes a range of problems.

What causes and risk factors for multiple myeloma? What triggers the malignancy of plasma cells in multiple myeloma is unknown. The cancerous myeloma plasma. Most likely, multiple myeloma has a variety of causes. These may include environmental factors like radiation exposure. It also seems to run in families. In. Multiple myeloma can cause pain in affected bones – usually the back, ribs or hips. The pain is frequently a persistent dull ache, which may be made worse by. Most of the medical problems related to myeloma are caused by the build-up of abnormal plasma cells in the bone marrow and the presence of the paraprotein in. While the exact cause of multiple myeloma is not known, scientists are learning how changes in DNA can cause plasma cells to become cancerous. DNA is the.

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